A/HRC/RES/49/27 9. Also expresses deep concern in particular about the recent increase in violence in the north-west of the Syrian Arab Republic, and the impact on civilians, civilian infrastructure and cultural property, including airstrikes, that have resulted in the deaths and injuries of many civilians, including women and children, and stresses the urgent need for the immediate cessation of military hostilities in Idlib and the surrounding areas, for the prioritization of the protection of all civilians, including those displaced, and for full, timely, immediate, unrestricted and safe humanitarian access, including cross-border and cross-line access; 10. Urges the Syrian authorities to share further information regarding the 344,684 detained and convicted persons who they have claimed have benefited from “amnesty laws”,6 and calls upon all parties to the conflict, but particularly the Syrian authorities, to cease all forms of abuse of detainees, including but not limited to torture of detainees in Syrian military intelligence facilities, physical abuses, mistreatment, and sexual and gender-based violence, and to grant appropriate international monitoring bodies and medical services immediate access, without undue restrictions, to detainees and detention facilities, including all Syrian military facilities referred to by the Commission of Inquiry in its reports, and highlights the recent recommendations of the Commission in this regard; 11. Reiterates its call for all States, relevant United Nations bodies, international organizations and civil society to coordinate further efforts and proactively focus attention on the issue of missing persons in the Syrian Arab Republic, including those subjected to enforced disappearance, recalls the importance of the full and meaningful participation of victims, survivors and their families in such efforts, and in this regard looks forward to the oral update of the Secretary-General to the General Assembly, pursuant to Assembly resolution 76/228 of 24 December 2021, on how to bolster efforts, including through existing measures and mechanisms, to clarify the fate and whereabouts of missing people in the Syrian Arab Republic, as well as to the report to follow by mid-2022; 12. Deplores the ongoing humanitarian crisis in the Syrian Arab Republic, notes the increasing needs, including for a sufficient supply of coronavirus disease (COVID-19) vaccines, across the Syrian Arab Republic, including in the north-east and the north-west, demands that all parties to the conflict comply with their applicable obligations under international human rights law and international humanitarian law and facilitate, and do not hinder, full, timely, immediate, unrestricted and safe humanitarian access, notes that humanitarian aid must be delivered on the basis of need, reiterates in this respect the continuing and urgent need for continued and expanded cross-border access to prevent further suffering and to save lives, and for immediate, rapid, unimpeded and sustained cross-line access, and calls for respect for humanitarian principles across the Syrian Arab Republic; 13. Expresses deep concern about the imposition of sieges, including the 2021 siege of Dar‘a al-Balad by the Syrian regime, which the Commission of Inquiry has indicated may amount to the war crime of collective punishment, which has resulted in shortages of necessities such as food, water and medicine and recurring service cuts to water distribution and electricity, recalls that international humanitarian law prohibits the starvation of civilians as a method of warfare and prohibits parties from attacking, destroying, removing or rendering useless objects that are indispensable to the survival of the civilian population, and in this regard implores all parties to the conflict to end any use of such methods; 14. Strongly condemns that the targeting of humanitarian workers and persons engaged in medical duties, their means of transport and equipment and hospitals and other medical facilities has been a feature of the conflict, recalls the findings of the Commission of Inquiry regarding the bombardment of the Atarib cave hospital on 21 March 2021 and the attack impacting Al-Shifa hospital on 12 June 2021, and demands that all parties to the conflict comply fully with their obligations under international law, including to ensure respect for and the protection of all persons engaged in medical duties, their means of transport and equipment and hospitals and all other medical facilities; 15. Also strongly condemns all acts of sexual and gender-based violence and abuse, recognizes the need for a survivor-centred approach to preventing and responding to 6 4 See A/HRC/WG.6/40/SYR/1.