E/2014/27 E/CN.6/2014/15 37. The Commission further recognizes that progress on the Millennium Development Goals for women and girls has been limited owing to the lack of systematic gender mainstreaming and integration of gender perspective in the design, implementation, monitoring and evaluation of the Goals. The Commission also recognizes that effective gender-responsive monitoring of the Goals has been limited owing to a lack of investment in and the consistent collection and use of reliable, integrated gender indicators, statistics and data, disaggregated by sex, age, disability, location and other relevant factors, and that goals, targets and indicators, including gender-sensitive indicators, are valuable in measuring and accelerating progress and are enhanced by voluntarily sharing information, knowledge and experience. The Commission acknowledges in this regard the importance of civil registration systems and vital statistics. 38. The Commission also recognizes that insufficient priority given to and significant underinvestment in gender equality and the empowerment of women in the realization of the human rights of women and girls continue to limit progress on the Millennium Development Goals for girls and women of all ages, their families and communities, and for the economic, social and environmental dimensions of sustainable development. It stresses that the available resources, through domestic resource mobilization and official development assistance, and their allocation remain a concern and are often inadequate to the task. 39. The Commission acknowledges the strategic and coordinating role of national machineries for the advancement of women, which should be placed at the highest possible level in government, for the achievement of gender equality and the implementation of the Millennium Development Goals for women and girls, and the need to endow these machineries with the necessary human and sufficient financial resources to enable them to function effectively. The Commission also acknowledges the contribution of national human rights institutions where they exist. 40. The Commission acknowledges the major contributions made by civil society, including women’s and community-based organizations and feminist groups, in placing the interests, needs and visions of women on national, regional and international agendas. 41. The Commission recognizes that all human rights are universal, indivisible and interdependent and interrelated and that the international community must treat human rights globally in a fair and equal manner, on the same footing and with the same emphasis, and stresses that, while the significance of national and regional particularities and various historical, cultural and religious backgrounds must be borne in mind, it is the duty of States, regardless of their political, economic and cultural systems, to promote and protect all human rights and fundamental freedoms. 42. The Commission urges Governments, at all levels, and as appropriate, with the relevant entities of the United Nations system, international and regional organizations, within their respective mandates and bearing in mind national priorities, and invites national human rights institutions where they exist, civil society, including non-governmental organizations, the private 14/95 14-02869